PUBLICATIONS
Robert M.
Williams, Colorado State University
1. º A stereoselective Synthesis of
Partially Substituted 1,2,3-Butatriene Derivatives via Hydroboration, Yoshida, T.; Williams,
R.M.; Negishi, E-i., J. Am. Chem. Soc., 1974, 96, 3688-3690.
2. º A Stereoselective Synthesis of
cis-Alkenylboranes,
Negishi, E-i.; Williams, R.M.; Lew, G.; Yoshida, T., J. Organomet. Chem., 1975, 92, C4-C6.
3. ¦ An Efficient Synthesis of
d,l-Gliovictin: Construction of the Hydroxymethyl Moiety via a
3-Formyl-2,5-Piperazinedione, Williams, R.M.; Rastetter, W.H., Tetrahedron
Lett., 1979, 1187-1190.
4. ¦ Synthesis of the Fungal Metabolites
(±)-Gliovictin and (±)-Hyalodendrin, Williams, R.M.; Rastetter, W.H., J. Org.
Chem., 1980, 45, 2625-2631.
5. ¤ Asymmetric Total Synthesis of
Erythromycin I,
Woodward, R.B.; Logusch, E.; Nambiar, K.P.; Sakan, K.; Ward, D.E.; Au-Yeung,
B.W.; Balaram, P.; Browne, L.J.; Card, P.J.; Chen, C.H.; Chenevert, R.B.;
Fliri, A.; Frobel, K.; Gais, H.J.; Garratt, D.G.; Hayakawa, K.; Heggie, W.;
Hesson, D.P.; Hoppe, D.; Hoppe, I.; Hyatt, J.A.; Ikeda, D.; Jacobi, P.A.; Kim,
K.S.; Kobuke, Y.; Kojima, K.; Krowicki, K.; Lee, V.J.; Leubert, T.; Malchenko,
S.; Martens, J.; Mathews, R.S.; Ong, B.S.; Press, J.B.; RajanBabu, T.V.;
Rousseau, G.; Sauter, H.M.; Suzuki, M.; Tatsuta, K.; Tolbert, L.M.; Truesdale,
E.A.; Uchida, I.; Ueda, Y.; Uyehara, T.; Vasella, A.T.; Vladuchick, W.C.; Wade,
P.A.; Williams, R.M.; Wong, H.N.-C. J. Am. Chem. Soc., 1981, 103, 3210-3213.
6. ¤ Asymmetric Total Synthesis of
Erythromycin II,
Woodward, R.B.; Logusch, E.; Nambiar, K.P.; Sakan, K.; Ward, D.E.; Au-Yeung,
B.W.; Balaram, P.; Browne, L.J.; Card, P.J.; Chen, C.H.; Chenevert, A.; Fliri,
A.; Frobel, K.; Gais, H.J.; Garratt, D.G.; Hayakawa, K.; Heggie, W.; Hesson,
D.P.; Hoppe, D.; Hoppe, I.; Hyatt, J.A.; Ikeda, D.; Jacobi, P.A.; Kim, K.S.;
Kobuke, Y.; Kojima, K.; Krowicki, K.; Lee, V.J.; Leubert, T.; Malchenko, S.;
Martens, J.; Mathews, R.S.; Ong, B.S.; Press, J.B.; RajanBabu, T.V.; Rousseau,
G.; Sauter, H.M.; Suzuki, M.; Tatsuta, K.; Tolbert, L.M.; Truesdale, E.A.;
Uchida, I.; Ueda, Y.; Uyehara, T.; Vasella, A.T.; Vladuchick, W.C.; Wade, P.A.;
Williams, R.M.; Wong, H.N.-C., J. Am. Chem. Soc., 1981, 103, 3213-3215.
7. ¤ Asymmetric Total Synthesis of
Erythromycin III,
Woodward, R.B.; Logusch, E.; Nambiar, K.P.; Sakan, K.; Ward, D.E.; Au-Yeung,
B.W.; Balaram, P.; Browne, L.J.; Card, P.J.; Chen, C.H.; Chenevert, R.B.;
Fliri, A.; Frobel, K.; Gais, H.J.; Garratt, D.G.; Hayakawa, K.; Heggie, W.;
Hesson, D.P.; Hoppe, D.; Hoppe, I.; Hyatt, J.A.; Ikeda, D.; Jacobi, P.A.; Kim,
K.S.; Kobuke, Y.; Kojima, K.; Krowicki, K.; Lee, V.J.; Leubert, T.; Malchenko,
S.; Martens, J.; Mathews, R.S.; Ong, B.S.; Press, J.B.; RajanBabu, T.V.;
Rousseau, G.; Sauter, H.M.; Suzuki, M.; Tatsuta, K.; Tolbert, L.M.; Truesdale,
E.A.; Uchida, I.; Ueda, Y.; Uyehara, T.; Vasella, A.T.; Vladuchick, W.C.; Wade,
P.A.; Williams, R.M.; Wong, H.N.-C., J. Am. Chem. Soc., 1981, 103, 3215-3217.
º Syracuse University
¦
MIT
¤ Harvard University
*Colorado
State University
1981
8. *Bicyclomycin
Synthetic Studies: Utilization of
Bridgehead Carbanions,
Williams, R. M., Tetrahedron Lett., 1981, 22, 2341-2344.
1982
9. *A
New and Efficient Cyclization Reaction to Construct the Bicyclomycin Ring
System: Synthesis of N,NÕ-Dimethyl-4-des-methylene Bicyclomycin, Williams, R.M.;
Anderson, O.P.; Armstrong, R.; Josey, J.; Meyers, H.; Eriksson, C., J. Am.
Chem. Soc.,
1982,
104,
6092-6099.
1983
10. *C-Glycosidation
of Pyridyl Thioglycosides, Williams, R.M.; Stewart, A.O., Tetrahedron Lett., 1983, 24, 2715-2718.
11. *Regioselective
Functionalization of Bicyclic Piperazinedione Bridgehead Carbanions, Williams, R.M.; Dung,
J-S.; Josey, J.; Armstrong, R.W.; Meyers, H., J. Am. Chem. Soc., 1983, 105, 3214-3220.
12. *Improved
Synthesis and Absolute Configuration of (+)- and
(-)-2,2,4-Trimethyl-1,3-dioxolane-4-carboxaldehyde, Dung, J-S.; Armstrong,
R.W.; Anderson, O.P.; Williams, R.M., J. Org. Chem., 1983, 48, 3592-3594.
1984
13. *Metal-Mediated
Concomitant Silyl Ether Cleavage/Cyclization Reactions to Construct Bicyclic
Piperazinediones and a New Polymer-Supported Hg(II) Perchlorate, Dung, J-S.; Armstrong,
R.W.; Williams, R.M., J. Org. Chem., 1984, 49, 3416-3419.
14. *Alternate
Preparation of Methyl-3-amino-2,3,6-trideoxy-a-D-arabino-hexopyranoside and Chiral Intermediates
for the Synthesis of Thienamycin, Stewart, A.O.; Williams, R.M., Carbohydrate
Res., 1984, 135, 167-173.
15. *Stereocontrolled
Total Synthesis of (±)- and (+)-Bicyclomycin: New Carbon-Carbon Bond-Forming
Reactions on Electrophilic Glycine Anhydride Derivatives, Williams, R.M.;
Armstrong, R.W.; Dung, J-S., J. Am. Chem. Soc., 1984, 106, 5748-5750.
1985
16. *Synthesis
and Antimicrobial Evaluation of Bicyclomycin Analogs, Williams, R.M.;
Armstrong, R.W.; Dung, J-S., J. Med. Chem., 1985, 28, 733-740.
17. *Unusual
Bridgehead Hydroxylations via Selenoxides: Evidence for Bridgehead Carbocations, Williams, R.M.; Dung,
J-S., Tetrahedron Lett., 1985, 26, 37-38.
18. *A
Divergent Generalized Synthesis of Unsymmetrically Substituted
2,5-Piperazinediones,
Williams, R.M.; Armstrong, R.W.; Maruyama, L.K.; Dung, J-S.; Anderson, O.P., J.
Am. Chem. Soc.,
1985,
107,
3246-3253.
19. *Stereocontrolled
Total Synthesis of (±)- and (+)-Bicyclomycin, Williams, R.M.; Armstrong, R.W.; Dung,
J-S., J. Am. Chem. Soc., 1985, 107, 3253-3266.
20. *C-Glycosidation
of Pyridyl Thioglycosides, Stewart, A.O.; Williams, R.M., J. Am. Chem. Soc., 1985, 107, 4289-4296.
21. *Thiolate
Additions to Bicyclomycin and Analogues: A Structurally Novel Latent
Michael-Acceptor System, Williams, R.M.; Tomizawa, K.; Armstrong, R.W.; Dung, J-S.,
J. Am. Chem. Soc.,
1985,
107,
6419-6421.
1986
22. *Electrophilic
Glycinates: New and Versatile Templates for Asymmetric Amino Acid Synthesis, Sinclair, P.J.; Zhai,
D.; Reibenspies, J.; Williams, R.M., J. Am. Chem. Soc., 1986, 108, 1103-1104.
23. *Promising
Cyclization Reactions to Construct the Ring Systems of Brevianamides A,B, Williams, R.M.;
Glinka, T., Tetrahedron Lett., 1986, 27, 3581-3584.
24. *Asymmetric
Synthesis of (R)- and (S)-[2-2H1]-Glycine, Williams, R.M.; Zhai,
D.; Sinclair, P.J., J. Org. Chem., 1986, 51, 5021-5022.
25. *Synthesis
of a Bicyclo[4.1.1] b-Lactam: A Novel,
Anti-Bredt b-Lactam, Williams, R.M.; Lee,
B., J. Am. Chem. Soc., 1986, 108, 6431-6433.
1987
26. *A
New Synthetic Approach to
1-Hydroxymethyl-8-methoxy-1,2,3,4-tetrahydro-isoquinolin-4-one, Williams, R.M.; Zhai,
W.; Ehrlich, P.P.; Hendrix, J., J. Org. Chem., 1987, 52, 2615-2617.
27. *Mechanism,
Biological Relevance and Structural Requirements for Thiolate Additions to
Bicyclomycin and Analogues: A Unique Latent Michael Acceptor System, Williams, R.M.;
Tomizawa, K.; Armstrong, R.W.; Dung, J-S., J. Am. Chem. Soc., 1987, 109, 4028-4035.
28. *Synthesis
of Functionalized Bicyclic Dioxopiperazines via Intramolecular Epoxide Opening, Williams, R.M.;
Maruyama, L.K., J. Org. Chem., 1987, 52, 4044-4047.
1988
29. *Alkynylation
of Mixed Haloacetals with Organotin Acetylides, Zhai, D.; Zhai, W.;
Williams, R.M., J. Am. Chem. Soc., 1988, 110, 2501-2505.
30. *Practical
Asymmetric Synthesis of a-Amino
Acids through Carbon-Carbon Bond Constructions on Electrophilic Glycine
Templates,
Williams, R.M.; Sinclair, P.J.; Zhai, D.; Chen, D., J. Am. Chem. Soc., 1988, 110, 1547-1557.
31. *Bicyclomycin:
Synthetic, Mechanistic and Biological Studies, Williams, R.M.; Durham, C.A., Chemical
Reviews,
1988,
88,
511-540.
32. *Asymmetric
Synthesis of b-Carboxy Aspartic
Acid (Asa),
Williams, R.M.; Sinclair, P.J.; Zhai, W., J. Am. Chem. Soc., 1988, 110, 482-483.
33. *Synthesis
of Verruculotoxin,
Williams, R.M.; Brunner, E.J.; Sabol, M.R., Synthesis, 1988, 963-966.
34. *Versatile
New Approach to the Synthesis of Monosubstituted and Bicyclic
Piperazine-2,5-diones: Unusual in situ Generation
and Enolate Addition to a Cumulene, Williams, R.M.; Kwast, A., J. Org. Chem., 1988, 53, 5785-5787.
35. *Asymmetric
Synthesis of a-Amino Acids:
Comparison of Enolate vs Cation Functionalization of
N-BOC-5,6-Diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-ones, Williams, R.M.; Im,
M-N., Tetrahedron Lett., 1988, 29, 6075-6078.
36. *Versatile,
stereocontrolled, Asymmetric Synthesis of E-Vinylglycine Derivatives, Williams, R.M.; Zhai,
W., Tetrahedron,
1988,
44, 5425-5430.
37. *Facial
Selectivity of the Intramolecular SN2Õ
Cyclization: Stereocontrolled Total Synthesis of Brevianamide B, Williams, R.M.;
Glinka, T.; Kwast, E., J. Am. Chem. Soc., 1988, 110, 5927-5929.
38. *Synthesis
and X-Ray Crystal Structure Determination of 1,3-Bridged b-Lactams: Novel,
Anti-Bredt b-Lactams, Williams, R.M.; Lee,
B-H.; Miller, M.M.; Anderson, O.P., in Recent Advances in the Chemistry of b-Lactam Antibiotics, Royal Society of
Chemistry, London 1988 pp. 106-118.
1989
39. *Synthesis
and X-Ray Crystal Structure Determination of 1,3-Bridged b-Lactams: Novel,
Anti-Bredt b-Lactams, Williams, R.M.; Lee,
B.H.; Miller, S.; Anderson, O.P., J. Am. Chem. Soc., 1989, 111, 1073-1081.
40. *Carbanion-Mediated
Oxidative Deprotection of Non-Enolizable Benzylated Amides, Williams, R.M.; Kwast,
E., Tetrahedron Lett., 1989, 30, 451-454.
41. *Remarkable,
Enantio-Divergent Biogenesis of Brevianamide A and B, Williams, R.M.; Kwast,
E.; Coffman, H.; Glinka, T., J. Am. Chem. Soc., 1989, 111, 3064-3065.
42. *Synthetic
studies on FR900482: Promising Method to Construct the Bicyclic Hydroxylamine
Hemi-Ketal Ring System, Yasuda, N.; Williams, R.M., Tetrahedron Lett., 1989, 30, 3397-3400.
43. *Synthetic
Studies on Paraherquamide: Regioselectivity of Indole Oxidation, Williams, R.M.; Glinka,
T.; Kwast, E., Tetrahedron Lett., 1989, 30, 5575-5578.
44. *Synthesis
of Optically Active a-Amino Acids, Williams, R.M.,
Pergamon Press, 1989, Oxford, (Organic Chemistry Series, Baldwin, J.E., Series
Editor). 410 pp.
1990
45. *Synthesis
of Ethynylglycine (FR900130), Williams, R.M.;Aldous, D.J.; Aldous, S.C., J.
Chem. Soc.
Perkin Trans I Comm., 1990, 171-172.
46. *Asymmetric
Synthesis of Arylglycines, Williams, R.M.; Hendrix, J.A., J. Org. Chem., 1990, 55, 3723-3728.
47. *Asymmetric,
Stereocontrolled Total Synthesis of (-)-Brevianamide B, Williams, R.M.;
Glinka, T.; Kwast, E.; Coffman, H.; Stille, J.K., J. Am. Chem. Soc., 1990, 112, 808-821.
48. *General
Synthesis of b,g-Alkynylglycine
Derivatives,
Williams, R.M.; Aldous, D.J.; Aldous, S.C., J. Org. Chem., 1990, 55, 4657-4663.
49. *Synthetic
Studies on Aspirochlorine (A30641), Williams, R.M.; Miknis, G.F., Tetrahedron
Lett., 1990, 31, 4297-4300.
50. *Synthetic
Studies on Paraherquamide: Synthesis of the 2H-1,5-Benzodioxepin Ring System, Williams, R.M.;
Cushing, T.D., Tetrahedron Lett., 1990, 31, 6325-6328.
51. *Identification
of a Novel Structural Class of Positive Modulators of the N-Methyl-D-Aspartate
Receptor, Whose Actions are Mediated Through the Glycine Recognition Site, Monahan, J.B.; Hood,
W.F.; Compton, R.P.; Cordi, A.A.; Williams, R.M., Eur. J. Pharmacol., 1990, 189, 373-379.
1991
52. º Highly Stereoselective Synthesis of
Conjugated E,E- and E,Z-Dienes, E-Enynes and E-1,2,3-Butatrienes via
Alkenylborane Derivatives, Negishi, E.; Yoshida, T.; Abramovitch, A.; Lew, G.;
Williams, R.M., Tetrahedron, 1991, 47, 343-356.
53. *Synthesis,
Conformation, Crystal Structures and DNA Cleavage Abilities of Tetracyclic
Analogs of Quinocarcin, Williams, R.M.; Glinka, T.; Gallegos, R.; Ehrlich, P.;
Flanagan, M.E.; Coffman, H.; Park, G., Tetrahedron (Symposium-in-Print), 1991, 47, 2629-2642.
54. *Synthesis
of Tri-Substituted Furans: Mild Ti(IV)-Mediated Couplings to Acetals.
Construction of the Epoxy Hemi-Amido Ketal of Fusarin C, Williams, R.M.;
Esslinger, C.S., Tetrahedron Lett., 1991, 32, 3635-3638.
55. *Novel
Ring Contractions via 2,3-Wittig Rearrangements: Synthesis of
(2-Desoxy)-2-Methylene Bicyclomycin, Williams, R.M.; Sabol, M.R.; Kim, H.; Kwast,
A., J. Am. Chem. Soc., 1991, 113, 6621-6633.
56. *Asymmetric
Synthesis of 2,6-Diamino-6-hydroxymethylpimelic Acid: Assignment of
Stereochemistry,
Williams, R.M.; Im, M-N.; Cao, J., J. Am. Chem. Soc., 1991, 113, 6976-6981.
57. *Asymmetric
Synthesis of 1-Aminocyclopropane Carboxylic Acid Derivatives, Williams, R.M.;
Fegley, G.J., J. Am. Chem. Soc., 1991, 113, 8796-8806.
58. *Asymmetric
Synthesis of Mono-Substituted and a,a-Disubstituted a-Amino Acids via Diastereoselective Glycine Enolate
Alkylations,
Williams, R.M.; Im, M-N., J. Am. Chem. Soc., 1991, 113, 9276-9286.
59. *Cannizzaro-Based
O2-Dependent Cleavage of DNA by Quinocarcin, Williams, R.M.; Glinka,
T.; Flanagan, M.E.; Gallegos, R.; Coffman, H.; Pei, D., Advances in New Drug
Development,
The Pharmaceutical Society of Korea, Seoul 1991, 38-50.
1992
60. *Cannizzaro-Based
O2-Dependent Cleavage of DNA by
Quinocarcin,
Williams, R.M.; Glinka, T.; Flanagan, M.E.; Gallegos, R.; Coffman, H.; Pei, D.,
J. Am. Chem. Soc., 1992, 114, 733-740.
61. *Asymmetric
Synthesis of a-Amino Acids, Williams, R.M., Aldrichimica
Acta, 1992, 25, 11-25.
62. *Preparation
of 4-Methoxy-4Õ-nitrobiphenyl, Stille, J.K.; Echavarren, A.M.; Williams, R.M.;
Hendrix, J.A., Org. Synth., 1992, 71, 97-106.
63. *Asymmetric
Synthesis of Arylglycines, Williams, R.M.; Hendrix, J.A., Chem. Rev., 1992, 92, 889-917.
64. *DNA
Cross-Linking Studies on FR-900482: Observations on the Mode of Activation, Williams, R.M.;
Rajski, S.R., Tetrahedron Lett., 1992, 33, 2929-2932.
65. *Asymmetric
Synthesis of 2,6-Diaminopimelic Acids, Williams, R.M.; Yuan, C., J. Org. Chem., 1992, 57, 6519-6527.
66. *Asymmetric
Synthesis of S-(-)-Cucurbitine, Williams, R.M.; Fegley, G.J., Tetrahedron
Lett., 1992, 33, 6755-6758.
67. *Asymmetric
[1,3]-Dipolar Cycloaddition Reactions: Synthesis of Highly Substituted Proline
Derivatives,
Williams, R.M.; Zhai, W.; Aldous, D.J.; Aldous, S.C., J. Org. Chem., 1992, 57, 6527-6532.
68. *Design
and Synthesis of Biologically Active Peptide Mimics, Williams, R.M., The
Development and Utilization of Biologically Active Peptides, Technomic Publishing
Co., Lancaster, PA 1992, p. 187-215.
1993
69. *Total
Synthesis of Aspirochlorine, Williams, R.M.; Miknis, G.F., J. Am. Chem. Soc., 1993, 115, 536-547.
70. *Biosynthesis
of the Brevianamides: Quest for a Biosynthetic Diels-Alder Cyclization, Sanz-Cervera, J.-F.;
Glinka, T.; Williams, R.M., J. Am. Chem. Soc., 1993, 115, 347-348.
71. *Biosynthesis
of Brevianamides A and B: In Search of the Biosynthetic Diels-Alder
Construction,
Sanz-Cervera, J.F.; Glinka, T.; Williams, R.M., Tetrahedron, 1993, 49, 8471-8482.
72. *Determination
of DNA Cross-Linking Sequence Specificity of FR66979: Observations on the Mode
of Action of the FR900482 Class of Anti-tumor Compounds, Williams, R.M.;
Rajski, S.R., Tetrahedron Lett., 1993, 44, 7023-7026.
73. *Stereocontrolled
Total Synthesis of (+)-Paraherquamide B, Cushing, T.D.; Sanz-Cervera, J.F.; Williams,
R.M., J. Am. Chem. Soc., 1993, 115, 9323-9324.
74. *Asymmetric
Synthesis of 1S,2R-(+)-2-Phenyl-1-Aminocyclopropane-1-Carboxylic Acid, Williams, R.M.;
Fegley, G.J., J. Org. Chem., 1993, 58, 6933-6935.
75. *Stereoselective
Synthetic and Mechanistic Chemistry of Bicyclomycin, Williams, R.M., Studies
in Natural Products Chemistry, Atta-ur-Rahman, Editor, Elsevier Pub., 1993,
Amsterdam, Vol. 12.
76. *Vinyl
Glycine Derivatives for Memory and Learning Enhancement or Treatment of a
Cognitive Disorder,
Cordi, A.A.; Monahan, J.B.; Williams, R.M., U.S. Patent No. 5,208,260, May 4, 1993.
1994
77. *O2-Dependent Cleavage of DNA by
Tetrazomine,
Williams, R.M.; Flanagan, M.E.; Tippie, T., Biochemistry, 1994, 33, 4086-4092.
78. *Asymmetric
Synthesis of g-D(L)-Glutamyl-L-meso-Diaminopimelic
Acid Dipeptide,
Williams, R.M.; Yuan, C., J. Org. Chem., 1994, 59, 6190-6193.
79. *A
New Method for Hydroxymethylene Peptide Isostere Synthesis: Asymmetric
Synthesis of Statine,
Williams, R.M.; Colson, P-J.; Zhai, W., Tetrahedron Lett., 1994, 35, 9371-9374.
80. *FR66979
Requires Reductive Activation to Cross-Link DNA Efficiently, Huang, H.; Rajski,
S.R.; Williams, R.M.; Hopkins, P.B., Tetrahedron Lett., 1994, 35, 9669-9672.
1995
81. *Netropsin
and Spermine Conjugates of a Water-Soluble Quinocarcin Analog: Analysis of
Sequence-Specific DNA Interactions, Flanagan, M.E.; Rollins, S.B.; Williams, R.M.,
Chem. Biol.,
1995,
2,
147-156.
82. *Asymmetric
Synthesis of a-Amino Acids, Williams, R.M., Advances
in Asymmetric Synthesis, JAI Press 1995, Volume 1 (pp 45-94) A. Hassner, Ed.
83. *Studies
on the Biosynthesis of Taxol: Total Synthesis of Taxa-4(20),11(12)-diene and
Taxa-4(5),11(12)-diene. The First Committed Biosynthetic Intermediate, Rubenstein, S.M.;
Williams, R.M., J. Org. Chem., 1995, 60, 7215-7223.
84. *Synthetic
Studies on Quinocarcin: Total Synthesis of (+)-Quinocarcinamide via
Dipole Cycloaddition of an Azomethine Ylide Generated by Novel NBS Oxidation, Flanagan, M.E.;
Williams, R.M., J. Org. Chem., 1995, 60, 6791-6797.
85. *Amino
Acid Synthesis,
Williams, R.M., Molecular Biology and Biotechnology. A Comprehensive Desk
Reference, VCH,
Weinheim, Meyers, R.A., Ed., 1995, Volume 1, pp 28-33.
86. Development
of GM-CSF Antagonist Peptides, VonFeldt, J.M.; Monfardini, C.; Fish, S.;
Rosenblum, H.; Kieber-Emmons, T.; Williams, R.M.; Kahn, S.A.; Weiner, D.B.;
Williams, W.V., Pept. Res., 1995, 8, 20.
1996
87. *Amino
Acid Synthesis,
Williams, R.M., The Encyclopedia of Molecular Biology and Molecular
Medicine, VCH,
Weinheim, R.A. Meyers, Ed., 1996, Volume 1, pp 52-58.
88. *Stereocontrolled
Total Synthesis of (+)-Paraherquamide B, Cushing, T.D.; Sanz-Cervera, J.F.; Williams,
R.M., J. Am. Chem. Soc., 1996, 118, 557-579.
89. *Asymmetric
Synthesis of (2S,3S,6S)-, (2S,3S,6R)-, and
(2R,3R,6S)-2,3-Methano-2,6-diaminopimelic Acids. Studies Directed to the Design
of Novel Substrate-based Inhibitors of L,L-Diaminopimelate Epimerase, Williams, R.M.;
Fegley, G.J.; Pruess, D.L.; Schaeffer, F., Tetrahedron, 1996, 52, 1149-1164.
90. *Photochemical
Cycloaromatization Reactions of ortho-Dialkynylarenes. A New Class of DNA
Photocleaving Agents,
Funk, R.L.; Young, E.R.R.; Williams, R.M.; Flanagan, M.A.; Cecil, T.R., J.
Am. Chem. Soc.,
1996,
118,
3291-3292.
91. *An
Efficient Method for the Preparation of Amidinoureas, Williams, R.M.; Yuan,
C., Tetrahedron Lett., 1996, 37, 1945-1948.
92. *Studies
on the Biosynthesis of Paraherquamide: Origin of the b-Methylproline Ring, Stocking, E.;
Sanz-Cervera, J.F.; Williams, R.M.; Unkefer, C.J., J. Am. Chem. Soc., 1996, 118, 7008-7009.
Errata: J. Am. Chem. Soc., 1997, 119, 9588.
93. *
Studies on the Total Synthesis of Paraherquamide A. Stereocontrolled,
Asymmetric Synthesis of a-Alkyl-b-Hydroxyproline Derivatives, Williams, R.M.; Cao,
J., Tetrahedron Lett., 1996, 37, 5441-5444.
94. *Cytochrome
P-450-Catalyzed Hydroxylation of Taxa-4(5),11(12)-diene to
Taxa-4(20),11(12)-diene-5-a-ol:
The First Oxygenation Step in Taxol Biosynthesis, Hefner, J.; Rubenstein, S.M.;
Ketchum, R.E.B.; Gibson, D.M.; Williams, R.M., Croteau, R. Chem. Biol., 1996, 3, 479-489.
1997
95. *FR900482,
a Close Cousin of Mitomycin C that Exploits Mitosene-Based Cross Linking, Williams, R.M.;
Rajski, S.R.; Rollins, S.B., Chem. Biol., 1997, 4, 127-137.
96. *Biosynthesis
of the Brevianamides: A Theoretical Study of the Biosynthetic Diels-Alder
Cyclization,
Domingo, L.R.; Sanz-Cervera, J.F.; Williams, R.M.; Picher, M.T.; Marco, J.A., J.
Org. Chem., 1997, 62, 1662-1667.
97. *Synthetic
Studies on FR900482. Synthesis of a Photo-triggered Pro-Mitosene, Rollins, S.B.;
Williams, R.M., Tetrahedron Lett., 1997, 38, 4033-4036.
98. *An
Efficient Synthesis of (S)-meta-Tyrosine, Bender, D.M.; Williams, R.M., J. Org.
Chem., 1997, 62, 6690-6691.
99. *Total
Synthesis of the Anti-MRSA Peptide Antibiotics TAN-1057A-D, Yuan, C.C.; Williams,
R.M., J. Am. Chem. Soc., 1997, 119, 11,777-11,784.
100. Biologically
Active Compounds and Methods of Constructing and Using the Same; Greene, M.I.;
Williams, W.V.; Weiner, D.B.; Cohen, J.A.; Kieber-Emmons, T.; Williams, R.M.; U.S.
Patent No. 5,637,677, June 11, 1997.
1998
101. *Biomimetic
Diels-Alder Cyclizations for the Construction of the Brevianamide,
Paraherquamide and VM55599 Ring Systems, Williams, R.M.; Sanz-Cervera, J.F.; Sancenon,
F., Marco, J.A.; Halligan, K.; J. Am. Chem. Soc., 1998, 120, 1090-1091.
102. *Synthesis
and Antimicrobial Evaluation of TAN-1057A/B Analogs, Williams, R.M.; Yuan,
C.; Lee, V.J.; Chamberland, S., J. Antibiot., 1998, 51, 189-201.
103. *FR-66979
Covalently Cross-Links the Binding Domain (BD) of the High Mobility Group
I/Y(HMG I/Y) Proteins to DNA, Rajski, S.R., Rollins,
S.B.; Williams, R.M., J. Am. Chem. Soc.,
1998, 120,
2192-2193.
104. *Asymmetric
Synthesis of Differentially Protected 2,7-Diaminosuberic Acid, A Ring-Closure
Metathesis Approach,
Williams, R.M.; Liu, J., J. Org. Chem., 1998, 63, 2130-2132.
105. *General
Asymmetric Synthesis of Hydroxymethylene and Hydroxyethylene Peptide Isosteres, Williams, R.M.; Aoyagi,
Y., Tetrahedron (Symposium-in-Print), 1998, 54, 10419-10433.
106. *Synthetic
Studies on Tetrazomine: Assignment of Stereochemistry of the b-Hydroxypipecolic
Acid. Scott,
J.D.; Tippie, T.N.; Williams, R.M., Tetrahedron Lett. 1998, 39, 3659-3662.
107. *Efficient
Asymmetric Synthesis of (S)-2-Methylasparagine. Aoyagi, Y.; Williams,
R.M., Syn. Lett.
1998,
1099-1101.
108. *Biomimetic
Diels-Alder Cyclizations for the Construction of the Brevianamide,
Paraherquamide, Sclerotamide, Asperparaline and VM55599 Ring Systems. Williams, R.M.; Sanz-Cervera,
J.F.; Sancen—n, F.; Marco, J.A.; Halligan, K., Bioorg. & Med. Chem. 1998, 6, 1233-1241.
109. *DNA
Interstrand Cross-Link Formation Induced by Bioxalomycin a2. Williams, R.M.;
Herberich, B., J. Am. Chem. Soc., 1998, 120, 10272-10273.
110. *Asymmetric
Synthesis of 1-BOC-3- and 4-Hydroxypyrrolidines. Aoyagi, Y.; Williams,
R.M., Tetrahedron,
1998,
54,
13045-13058.
111. *DNA Interstrand Cross-Linking Agents as
Antitumor Drugs.
Rajski, S.R.; Williams, R.M., Chem. Rev. 1998, 98, 2723-2796.
1999
112. *Asymmetric
Syntheses of Unnatural Amino Acids and Hydroxyethylene Peptide Isosteres. Williams, R.M., Humana
Press, Peptidomimetics Protocols, Kazmierski, W., Ed., Totowa, 1999, Vol. 23, Chapter 19, pp. 339-356.
113. *Reverse
versus Normal Prenyl Transferases in Paraherquamide Biosynthesis Exhibit
Distinct Facial Selectivities. Stocking. E.; Sanz-Cervera, J.F.; Williams,
R.M., Angew. Chemie Int. Ed Engl. 1999, 38, 786-789.
114. *DNA
Cross-Linking by a Phototriggered Dehydromonocrotaline Progenitor. Williams, R.M.; Tepe,
J., J. Am. Chem. Soc., 1999, 121, 2951-2955.
115. *Synthetic
Studies on Asperparaline A. Synthesis of the Spriosuccinimide Ring System. Gonzalez, F.; Williams,
R.M., Tetrahedron Lett. 1999, 40, 4519-4522.
116. *Reductive
Activation of a Hydroxylamine Hemi-acetal Derivative of Dehydromonocrotaline.
The First Reductively Activated Pyrrolizidine Alkaloid Capable of Cross-linking
DNA.
Tepe, J.J.; Williams, R.M., Angew. Chemie Int. Ed Engl. 1999, 38, 3501-3503.
2000
117. *Synthesis
of the First Photo-triggered Pro-Mitosene Based on FR-900482. Williams, R.M.;
Rollins, S.B.; Judd, T.C., Tetrahedron, 2000, 56, 521-532.
118. *Total
Synthesis of VM55599. Utilization of an Intramolecular Diels-Alder
Cycloaddition of Potential Biogenetic Relevance. Stocking, E.M.;
Sanz-Cervera, J.F.; Williams, R.M., J. Am. Chem. Soc. 2000, 122, 1675-1683.
119. *Synthesis
of Stable and Radioisotopomers of Taxa-4(5),11(12)-diene, Taxa-4(20),11(12)-diene
and Taxa-4(20),11(12)-dien-5-a-ol. Early Intermediates in Taxol Biosynthesis. Rubenstein, S. M.;
Vazquez, A.; Williams, R.M., J. Labeled Cmpd & Radiopharm. 2000, 43, 481-491.
120. *Synthesis
of a Netropsin Conjugate of a Water-Soluble Epi-quinocarcin Analog: The
Importance of Stereochemistry at Nitrogen. Herberich, B.; Scott, J.D.; Williams,
R.M., Bioorg. Med. Chem., 2000, 8, 523-532.
121. *Biosynthesis
of Prenylated Alkaloids Derived from Tryptophan. Williams, R.M.;
Sanz-Cervera, J.F.; Stocking, E., in Topics in Current Chemistry, Volume on Biosynthesis-Terpenes
and Alkaloids,
Leeper, F.; Vederas, J.C., Eds., Springer-Verlag, Berlin, 2000, 209, 97-173.
122. *The
Asymmetric Total Synthesis of (+)- and (-)-Spirotryprostatin B. Sebahar, P.; Williams,
R.M., J. Am. Chem. Soc. 2000, 122, 5666-5667.
123. *Observations
on the Covalent Cross-Linking of the Binding Domain (BD) of the High Mobility
Group I/Y (HMG I/Y) Proteins to DNA by FR66979. Rajski, S.R.; Williams,
R.M., Bioorg. Med. Chem. 2000, 8, 1331-1342.
124. *Asymmetric,
Stereocontrolled Total Synthesis of Paraherquamide A. Williams, R.M.; Cao,
J.; Tsujishima. H., Angew. Chem. Int. Ed. Engl. 2000, 39, 2540-2544.
125. *A Synthesis of
3Õ,5Õ-Dideoxy-5Õ-Aminouridine. Bender, D.M.; Hennings, D.D.; Williams, R.M., Synthesis 2000, 399-402.
126. *Synthesis
and Evaluation of Microtubule Assembly Inhibition and Cytotoxicity of
Prenylated Derivatives of cyclo-L-Trp-L-Pro. Sanz-Cervera, J.F.; Stocking, E.M.;
Usui, T.; Osada, H.; Williams, R.M., Bioorg. Med. Chem. 2000, 8, 2407-2415.
127. *Reverse
Prenyl Transferases Exhibit Poor Facial Discrimination in the Biosyntheses of
Paraherquamide, Brevianamide and Austamide. Stocking. E.M.; Sanz-Cervera, J.F.;
Williams, R.M., J. Am. Chem. Soc. 2000, 122, 9089-9098.
128. *Synthesis
of (S,S)- and (R,R)- 2-Amino-3-methylaminobutanoic Acid (AMBA). Hennings, D.D.;
Williams, R.M., Synthesis 2000, 1310-1314.
129. *A
Synthetic Model for the [4+2] Cycloaddition in the Biosynthesis of the
Brevianamides, Paraherquamides, and Related Compounds. Sanz-Cervera,
J.F.; Williams, R.M.; Marco, J.A.; L—pez-S‡nchez, J.M.; Gonz‡lez,
F.; Mart’nez, M.E.; Sancen—n, F., Tetrahedron 2000, 56, 6345-6358.
130. *New
FR900482 Class of Antitumor Drugs Cross-links Oncoprotein HMG I/Y in Vivo. Beckerbauer, L.; Tepe,
J.; Cullison J.; Reeves, R.; Williams, R.M., Chem. Biol. 2000, 7, 805-812.
131. *Synthetic
Studies on Tetrazomine: Lipase PS Resolution of Racemic cis-b-Hydroxypipecolic
Acid. Scott,
J.D.; Williams, R.M., Tetrahedron Lett. 2000, 41, 8413-8416.
132. *Intramolecular
Proton Transfer in the Cyclization of Geranylgeranyl Diphosphate to the
Taxadiene Precursor of Taxol Catalyzed by Recombinant Taxadiene Synthase. Williams, D.C.; Caroll,
B.J.; Jin, Q.; Rithner, C.D.; Lenger, S.R.; Floss, H.G.; Coates, R.A.;
Williams, R.M.; Croteau, R., Chem. Biol. 2000, 7, 969-977.
133. *Studies
on the Biosynthesis of Taxol. Synthesis of Taxa-4(20), 11(12)-dien-2a, 5a-diol. Vazquez, A.; Williams,
R.M., J. Org. Chem. 2000, 65, 7865-7869.
134. *Lipase
TL¨-Mediated Kinetic Resolution of Benzoin: Facile Synthesis of (1R,
2S)-erythro-2-Amino-1,2-diphenylethanol. Aoyagi, Y.; Agata, N.; Shibata, N.; Horiguchi,
M.; Williams, R.M., Tetrahedron Lett. 2000, 41, 10159-10162.
135. *Antibiotic
for Methicillin Resistant Bacteria. Williams, R.M.; Yuan, C., U.S. Patent No.
6,110,925, August 29, 2000.
136. *Antibiotic
for Methicillin Resistant Bacteria. Williams, R.M.; Yuan, C., U.S. Patent No.
6,162,925, December 19, 2000.
2001
137. *An Efficient Asymmetric
Synthesis of (2S, 3S)-b-Hydroxyornithine. DeMong, D.E.; Williams,
R.M., Tetrahedron Lett. 2001, 42, 183-185.
138. *Construction of the
A-ring of Cylindrospermopsin via an Intramolecular Oxazinone-N-oxide Dipolar
Cycloaddition.
Looper, R.; Williams, R.M., Tetrahedron Lett. 2001, 42, 769-771.
139. *Sequential
Staudinger/Pictet-Spengler Cyclization Reactions for the Construction of
Densely Functionalized Tetrahydroisoquinolines. Herberich, B.; Vazquez,
A.; Kinugawa, M.; Jin, W.; Williams, R.M., Tetrahedron Lett. 2001, 42, 543-546.
140. *Studies
on the Biosynthesis of Paraherquamide. Synthesis and Incorporation of a
Hexacyclic Indole Derivative as an Advanced Metabolite.
Stocking, E.M.; Sanz-Cervera, J.F.; Williams, R.M., Angew. Chem. Int. Ed.
Engl. 2001, 40,
1296-1298.
141. *Studies on the
Biosynthesis of Paraherquamide: Concerning the Mechanism of Oxidative
Cyclization of L-Isoleucine to b-Methylproline. Stocking, E.M.;
Martinez, R.A.; Silks, L.A.; Sanz-Cervera, J.F.; Williams, R.M., J. Am.
Chem. Soc. 2001, 123, 3391-3392.
142. *Molecular Cloning of a Cytochrome P450
Taxane 10-beta-Hydroxylase cDNA from Taxus and Functional
Expression in Yeast. Schoendorf,
A.; C. Rithner, C.; Williams R.M.; Croteau, R., Proc. Nat. Acad. Sci. USA 2001, 98, 1501-1506.
143. *Total Synthesis of
(-)-Tetrazomine and Determination of Its Stereochemistry. Scott, J.D.; Williams,
R.M. Angew. Chem.
Int. Ed. Engl.
2001,
40,
1463-1465.
144. *Entry into the
Bi-aryl Moiety of the TMC-95 Proteosome Inhibitors via the Stille Protocol. Albrecht, B.K.;
Williams, R.M., Tetrahedron Lett. 2001, 42, 2755-2757.
145. *Stereocontrolled
Asymmetric Synthesis of a-Hydroxy-b-Amino Acids. A
Stereodivergent Approach. Aoyagi, Y.; Jain, R.P.; Williams, R.M., J.
Am. Chem. Soc. 2001, 123, 3472-3477.
146. *Asymmetric
Synthesis of (S)-(+)-Carnitine and Analogs. Jain, R.P.; Williams,
R.M., Tetrahedron (Symposium-in-Print), 2001, 57, 6505-6509.
147.
*The Asymmetric Synthesis
of (2S,3R)-Capreomycidine. DeMong, D.E.; Williams, R.M., Tetrahedron
Lett.
2001,
42,
3529-3532.
148. *Asymmetric Synthesis
of (R)-(-)-Carnitine.
Jain, R.P.; Williams, R.M., Tetrahedron Lett. 2001, 42, 4437-4440.
149. *Studies on the
Biosynthesis of Paraherquamide: Construction of the Amino Acid Framework. Stocking, E.;
Sanz-Cervera, J.F.; Unkefer, C.J.; Williams, R.M., Tetrahedron. 2001, 57, 5303-5320.
150. *DNA Cross-linking
by a Phototriggered Pyrrolic Progenitor Developed from Monocrotaline. Kosogof, C.; Tepe,
J.J.; Williams, R.M., Tetrahedron Lett. 2001, 42, 6641-6643.
151. *Taxol Biosynthesis:
Differential Transformations of Taxadien-5a-ol and Its Acetate
Ester by Cytochrome P 450 Hydroxylases from Taxus Suspension
Cells.
Wheeler, A.L.; Long, R.M.; Ketchum, R.E.B.; Rithner, C.; Williams R.M.;
Croteau, R., Arch. Biochem. Biophys. 2001, 390, 265-278.
152. *Asymmetric Synthesis of [2,3-13C2, 15N]-4-Benzyloxy-5,6-diphenyl-2,3,5,6-tetrahydro-4H-oxazine-2-one
via Lipase TL¨-Mediated Kinetic Resolution of Benzoin: General
Procedure for the Synthesis of [2,3-13C2, 15N]-L-Alanine. Aoyagi, Y.; Iijima, A.; Williams, R.M., J. Org. Chem. 2001, 66, 8010-8014.
153. *Asymmetric
Synthesis of (+)-Hypusine. Jain, R.P.; Albrecht, B.K.; DeMong, D.E.;
Williams, R.M., Org. Lett. 2001, 3, 4287-4289.
154. *Taxol Biosynthesis:
Taxane 13a-Hydroxylase is a
Cytochrome P450-Dependent Monooxygenase. Jennewein, S.; Rithner,
C.D.; Williams, R.M.; Croteau, R., Proc. Nat. Acad. Sci. USA 2001, 98, 13595-13600.
2002
155. *Differential Effects of FR900482 and
FK317 on Apoptosis, IL-2 Gene Expression and Induction of Vascular Leak
Syndrome.
Beckerbauer, L.; Tepe, J.J.; Eastman, R.A.; Mixter, P.; Williams, R.M.; Reeves,
R., Chem. Biol.
2002,
8,
427-441.
156. *Asymmetric Total Synthesis of VM55599:
Establishment of the Absolute Stereochemistry and Biogenetic Implications. Sanz-Cervera, J.F.;
Williams, R.M., J. Am. Chem. Soc. 2002, 124, 2556-2559.
157. *Total Synthesis of (-)-Tetrazomine.
Determination of the Stereochemistry of Tetrazomine and the Synthesis and
Biological Activity of Tetrazomine Analogs. Williams, R.M.; Scott,
J.D., J. Am. Chem. Soc. 2002, 124, 2951-2956.
158. *Synthetic Studies Towards
Paraherquamide F: Synthesis of the 1,7-Dihydropyrano[2,3-g]indole Ring System. Cox, R.J.; Williams, R.M., Tetrahedron Lett. 2002, 43, 2149-2152.
159. *The First Asymmetric
Synthesis of (2S)- and (2R)-Amino-3,3-Dimethoxypropanoic Acid. DeMong, D.E.; Williams, R.M., Tetrahedron Lett. 2002, 43, 2355-2357.
160. *DNA Interstrand
Cross-link Formation by Reductive Activation of Dehydropyrrolizidine
Progenitors. Tepe,
J.J.; Kosogof, C.; Williams, R.M., Tetrahedron 2002, 58, 3553-3559.
161. *Chemistry and
Biology of the Tetrahydroisoquinoline Antitumor Antibiotics. Scott, J.D.; Williams, R.M., Chem. Rev. 2002, 102, 1669-1730.
162. *The
Synthesis and Biosynthesis of the Paraherquamides: An Intriguing Story of the
Biological Diels-Alder Construction. Williams, R.M., Chem.
Pharm. Bull.
2002,
50,
711-740 (invited review).
163. *Asymmetric,
Stereocontrolled Total Synthesis of (+)- and (-)-Spirotryprostatin B via a
Diastereoselective Azomethine Ylid [1,3]-Dipolar Cycloaddition Reaction. Sebahar, P.R.; Osada,
H.; Williams, R.M., Tetrahedron Symposium-in-Print, 2002, 58, 6311-6322.
164. *Studies on Taxol Biosynthesis.
Preparation of Taxa-4(20), 11(12)-dien-5a-acetoxy-10b-ol by Deoxygenation of
a Taxadiene Tetra-acetate Obtained from Japanese Yew. Horiguchi, T.;
Rithner, C.D.; Croteau, R.; Williams, R.M., J. Org. Chem. 2002, 67, 4901-4903.
165. *Asymmetric Synthesis of Spirooxindole
and 3,4 Dehydro-Proline Derivatives via Asymmetric Azomethine Ylide
[1,3]-Dipolar Cycloaddition Reactions. Sebahar, P.; Williams,
R.M., Heterocycles
2002,
58,
563-575.
166. *Asymmetric Synthesis of (+)-Negamycin. Jain, R.P.; Williams,
R.M., J. Org. Chem.
2002,
67,
6361-6365.
167. *DNA Cross-link Formation by a
Phototriggered Mitosene Progenitor. Judd, T.; Williams,
R.M., Org. Lett.
2002,
4,
3711-3714.
168. *Concise Enantioselective Synthesis of
(+)-FR66979 and (+)-FR900482: DMDO-Mediated Construction of the Hydroxylamine
Hemi-ketal.
Judd, T.; Williams, R.M., Angew. Chem. Int. Ed. Engl. 2002, 41, 4683-4685.
2003
169. *Studies on Taxol Biosynthesis.
Preparation of 2a, 10b-dihydroxy Taxadien-5a-yl Acetate Derivatives by Deoxygenation of
a Taxadiene Tetra-acetate Obtained from Japanese Yew. Horiguchi, T.;
Rithner, C.D.; Croteau, R.; Williams, R.M., Tetrahedron 2003, 59, 267-273.
170. *A Concise Formal Total Synthesis of
TMC-95A/B Proteasome Inhibitors. Albrecht, B.; Williams,
R.M., Org. Lett.
2003,
5,
197-200.
171. *The Paraherquamides, Brevianamides and
Asperparaline: Laboratory Synthesis and Biosynthesis. An Interim Report. Cox, R.J.; Williams,
R.M., Acc. Chem. Res. 2003, 36, 127-139.
172. *Asymmetric
Synthesis of N-tert-Butoxycarbonyl a-Amino Acids. Synthesis of (5S, 6R)- and (5R,
6S)-4-tert-Butoxycarbonyl-2,3-Diphenylmorpholin-6-one. Williams, R.M.;
Sinclair, P.J.; DeMong, D.; Chen, D.; Zhai, D., Org. Synth. 2003, 80, 18-30.
173. *Efficient
Asymmetric Synthesis of N-tert-Butoxycarbonyl a-Amino Acids Using
(tert-Butoxy)Carbonyl-2,3-Diphenylmorpholin-6-one. Preparation of
(R)-Allylglycine.
Williams, R.M.; Sinclair, P.J.; DeMong, D.E., Org. Synth. 2003, 80, 31-37.
174. *Synthetic Studies on
Ecteinascidin-743: Constructing a Versatile Pentacyclic Intermediate for the
Synthesis of Ecteinascidins & Saframycins. Jin, W.; Metobo, S.;
Williams, R.M., Org. Lett. 2003, 5, 2095-2098.
175. *Synthetic Studies
on Ecteinascidin 743: Asymmetric Synthesis of the Versatile Amino Acid
Component.
Jin,
W.; Williams, R.M., Tetrahedron Lett. 2003, 44, 4635-4639.
176. *Studies on the Biosynthesis of Paraherquamide A and
VM99955. A Theoretical Study for the Intramolecular Diels-Alder Cycloaddition. Domingo, L.R.; Zaragoz‡, R.J.; Williams, R.M., J.
Org. Chem.
2003,
68,
2895-2902.
177. Taxoid Metabolism:
Taxoid 14b-Hydroxylase is a
Cytochrome P450-Dependent Monooxygenase. Jennewein, S.; Rithner,
C.D.; Williams, R.M.; Croteau, R., Arch. Biochem. Biophys. 2003, 413, 262-270.
178. *Chemistry and
Biology of Biosynthetic Diels-Alder Reactions. Stocking, E., Williams,
R.M., Angew. Chem. Int. Ed. Engl. 2003, 42, 3078-3115.
179. *Asymmetric Synthesis of (2S,
3R)-Capreomycidine and the Total Synthesis of Capreomycin IB. DeMong,
D.E.; Williams, R.M., J. Am. Chem. Soc.
2003, 125,
8561-8565.
180. *Taxus
Metabolomics: Methyl Jasmonate Preferentially Induces Production of Taxoids
Oxygenated at C-13 in Taxus x media Cell Cultures. Ketchum, R.E.B.;
Rithner, C.D.; Qiu, D.; You Sun Kim, Y.S.; Williams, R.M.; Croteau R.B.,
Phytochem.
2003,
62,
901-909.
181. *Lipase TL¨-Mediated Kinetic Resolution of
5-Benzyloxy-1-tert-butyldimethylsilyloxy-2-pentanol in Low Temperature: Concise
Asymmetric Synthesis of Both Enantiomers of Piperazic Acid Derivative. Aoyagi, Y.; Saitoh, Y.; Ueno, T.; Horiguchi, M.; Takeya, K.; Williams, R.M., J.
Org. Chem. 2003, 68, 6899-6904.
182. *Concise Asymmetric Total Synthesis of
Spirotryprostatin A.
Onishi, T.; Sebahar, P.R.; Williams, R.M., Org. Lett. 2003, 5, 3135-3137.
183. *Asymmetric, Stereocontrolled Total Synthesis of
Paraherquamide A. Williams, R.M.; Cao, J.; Tsujishima, H., J.
Am. Chem. Soc. 2003, 125, 12172-12178.
184. *Interstrand Cross-linking of DNA by
FK-317 and Its Deacetylated Metabolites FR70496 and FR157471. Ducept, P.; Williams,
R.M., Biochemistry
2003,
42,
14696-14701.
185. *Studies on the Biosynthesis of
Asperparaline A. Origin of the Spiro-succinimide Moiety. Gray, C.; Sanz-Cervera,
J.F.; Williams, R.M., J. Am. Chem. Soc. 2003, 125, 14692-14693.
2004
186. *Cytochrome
P450 Taxadiene 5a-Hydroxylase,
a Mechanistically Unusual Monooxygenase Catalyzing the First Oxygenation Step
of Taxol Biosynthesis. Jennewein, S.; Long, R.M.; Williams, R.M.;
Croteau, R., Chem. Biol. 2004, 11, 379-387.
187. *A Concise Total Synthesis of
(+)-FR900482 and (+)-FR66979. Judd, T.C.; Williams, R.M., J. Org. Chem. 2004, 69, 2825-2830.
188. *Total Synthesis of
the TMC-95A/B Proteasome Inhibitors.
Albrecht, B.; Williams, R.M. Proc. Nat. Acad. Sci. USA 2004,
101,
11949-11954.
189. *Concise Synthesis of the Core
Bicyclo[2.2.2]diazaoctane Ring Common to Asperparaline, Paraherquamide and
Stephacidin Alkaloids.
Adams, L.A.; Gray, C.R.; Williams, R.M. Tetrahedron Lett. 2004, 45, 4489-4493.
190. *Concise, Asymmetric Total
Synthesis of Spirotryprostatin A. Onishi, T.; Sebahar,
P.R.; Williams, R.M. Tetrahedron 2004, 60, 9503-9515.
191. *A Concise Asymmetric Synthesis of the Marine
Hepatotoxin 7-Epi-cylindrospermopsin. Looper, R.E.; Williams,
R.M. Angew. Chem. Int. Ed. Engl. 2004, 43, 2930-2933.
192. *A
Concise Asymmetric Synthesis of the ADE Fragment of Nakadomarin A.
Ahrendt, K.A.; Williams, R.M. Org. Lett.
2004, 6,
4539-4541.
2005
193. *An
Improved Synthesis of Optically Pure 4-Boc-5,6-Diphenylmorpholin-2-one and
4-Cbz-5,6-Diphenylmorpholin-2-one. Dastlik, K.A.; Sundermeier, U.; Johns, D.M.; Chen,
Y.; Williams, R.M. Syn. Lett. 2005, 693-696.
194. *Synthesis of the
Putative Structure of 7-Deoxycylindrospermopsin: C7-Oxygenation is not Required
for the Inhibition of Protein Synthesis. Looper, R.E.; Runnegar,
M.T.C.; Williams, R.M., Angew. Chem. Int. Ed. Engl. 2005, 44, 3879-3881.
195. *Asymmetric Total
Synthesis of Jorumycin, Renieramycin G, 3-epi-Jorumycin and 3-epi-Renieramycin
G.
Lane, J.W.; Chen, Y.; Williams, R.M., J. Am. Chem. Soc. 2005, 127,
12684-12690.
196. Remarkable
Diastereomeric Rearrangement of an a-Acyloxy b-ketosulifide to an a-Acyloxy Thioester: A
Novel Approach to the Synthesis of Optically Active (2S,3S) b-Amino a-Hydroxy Acids. Suzuki, T.; Honda, Y.;
Izawa, K.; Williams, R.M. J. Org. Chem. 2005, 70, 7317-7323.
197. *Improved Synthesis by Mitsunobu Cyclization of the
Core Benzazocine Ring Precursor to FR900482 and the Mitomycins. Williams, R.M.; Ducept, P; Gubler, D.A., Heterocycles, invited paper 2006, 0000 (In Press).
198. *Concise Syntheses of
the 1,7-dihydropyrano[2,3-g]indole Ring System of the Stephacidins,
Paraherquamides and Norgeamides. Artman, G. D.; Grubbs,
A.W.; Williams, R.M. Tetrahedron Lett. 2005, 46, 0000 (In Press).
199. *Concise Synthesis of
Brevianamide B via a Biomimetically-inspired IMDA Construction. Adams, L.A.; Neissel,
M.W.; Williams, R.M. Tetrahedron Symposium-in-Print. 2006, 0000 (In Press).
200. *Studies
on Taxol Biosynthesis. Preparation and Tritium Labeling of Biosynthetic
Intermediates by Deoxygenation of a Taxadiene Tetra-acetate Obtained from
Japanese Yew.
Tohru Horiguchi, T.; Rithner, C.D.; Croteau, R.; Williams, R.M., Labeled
Cmpd. & Radiopharm. (in preparation).
201. *Diphenyloxazinones,
Versatile Templates for the Asymmetric Synthesis of Amino Acids and Peptide
Isosteres.
Jain, R.P.; Williams, R.M., Tetrahedron Reports (in preparation).
202. *Synthetic Studies on
Quinine. Novel Intramolecular SN2«
Strategy to Access the Quinuclidine Core. Synthesis of 7-Hydroxy Quinine. Mori, M.; Johns, D.M.;
Williams, R.M. Org. Lett. (in preparation).
203. *Versatile Synthesis
of C-20-epi-Stephacidin A Analogs. Neissel, M.W.;
Newkirk, T.; Williams, R.M. (in preparation).
204. *Synthesis of the
Cylindrospermopsin Alkaloids. Looper, R.E.; Runnegar, M.T.C.; Williams, R.M., Tetrahedron (submitted).
(1) Synthesis of Optically Active a-Amino Acids, Robert M. Williams,
Pergamon Press, 1989, Oxford, (The Organic Chemistry Series, J.E. Baldwin, Series
Editor). 410 pp.
(2) Organic & Biological Chemistry (undergraduate
textbook, under contract).
(3) Biosynthesis of Primary and
Secondary Metabolites
(submitted).
(4) Synthesis of Optically Active a-Amino Acids, 2nd Edition
Robert M. Williams, Pergamon Press, Oxford, (Organic Chemistry Series, J.E. Baldwin and
Robert M. Williams Series Editors).
1. Biosynthesis
of Prenylated Alkaloids Derived from Tryptophan. Williams, R.M.;
Sanz-Cervera, J.F.; Stocking, E., in Topics in Current Chemistry, Volume on Biosynthesis-Terpenes
and Alkaloids,
Leeper, F.; Vederas, J.C., Eds., Springer-Verlag, Berlin, 2000, 209, 97-173.
2. Asymmetric
Syntheses of Unnatural Amino Acids and Hydroxyethylene Peptide Isosteres, Williams, R.M., Humana
Press, Peptidomimetics Protocols, Kazmierski, W., Ed., Totowa, 1999, Chapter 19, pp. 339-356.
3. Amino
Acid Synthesis,
Williams, R.M., The Encyclopedia of Molecular Biology and Molecular
Medicine, VCH,
Weinheim, Meyers, R.A., Ed., Volume 1, pp 52-58, 1996.
4. Asymmetric
Synthesis of a-Amino Acids, Williams, R.M., Advances
in Asymmetric Synthesis, JAI Press Volume 1 (pp 45-94) A. Hassner, Ed., 1995.
5. Amino
Acid Synthesis,
Williams, R.M., Molecular Biology and Biotechnology. A Comprehensive Desk
Reference,
VCH, Weinheim, Meyers, R.A., Ed., Volume 1, pp 28-33, 1995.
6. Stereoselective
Synthetic and Mechanistic Chemistry of Bicyclomycin, Williams, R.M., Studies
in Natural Products Chemistry, Atta-ur-Rahman, Editor, Elsevier Pub.,
Amsterdam, Vol. 12 ,1993.
7. Design
and Synthesis of Biologically Active Peptide Mimics, Williams, R.M., The
Development and Utilization of Biologically Active Peptides, Technomic Publishing
Co., Lancaster, PA, 1992, p. 187-215.
8. Cannizzaro-Based
O2-Dependent Cleavage of DNA by
Quinocarcin,
Williams, R.M.; Glinka, T.; Flanagan, M.E.; Gallegos, R.; Coffman, H.; Pei, D. Advances
in New Drug Development, 1991, p.38-51, The Pharmaceutical Society of Korea, Seoul.
9. Synthesis
and X-Ray Crystal Structure Determination of 1,3-Bridged b-Lactams: Novel,
Anti-Bredt b-Lactams. in Recent Advances
in the Chemistry of b-Lactam Antibiotics, Williams, R.M.; Lee,
B-H.; Miller, M.M.; Anderson, O.P. Royal Society of Chemistry, London 1988 p. 106.
(1)
Vinyl Glycine Derivatives for Memory and Learning Enhancement or Treatment
of a Cognitive Disorder, A.A. Cordi, J.B. Monahan and R.M. Williams; U.S. Patent #
5,208,260, May 4, 1993.
(2)
Biologically Active Compounds and Methods of Constructing and Using the Same; Greene, Mark I.;
Williams, William V.; Weiner, David B.; Cohen, Jeffrey A.; Kieber-Emmons,
Thomas; Williams, Robert M.; U.S. Patent # 5,637,677, June 11, 1997.
(3)
Antibiotic for Methicillin Resistant Bacteria. R.M. Williams and C.
Yuan ; U.S. Patent # 6,110,925, August 29, 2000.
(4)
Antibiotic for Methicillin Resistant Bacteria. R.M. Williams and C.
Yuan ; U.S. Patent # 6,162,925, December 19, 2000.
News
Coverage of Published Work:
1. ÒNew Routes to Antitumor AntibioticsÓ, Chemical &
Engineering News,
December 16, 2002 (Highlights
of Angew. Chem. Int. Ed. Engl. 2002, 41, 4683-4685).
2. "Key Step in Taxol Biosynthesis
Revealed", Chemical & Engineering News, December 11, 2000, Stu Borman (Highlights
of Chem. Biol.
2000,
7,
969-977).
3. "Researchers Probe Steps of Taxol
Biosynthesis"
Chemical & Engineering News, July 1, 1996, Stu Borman,
(Highlights of Chem. Biol., 1996, 3, 479-489).