Cameron Burnett
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Studies towards the total synthesis of microsclerodermin G

 

     The marine natural product microsclerodermin G (1) was isolated in 2000 from a Microscleroderma sponge by Faulkner et al.1 Microsclerodermin G inhibits growth of the HCT-116 human colon carcinoma cell line and exhibits antiproliferative activity against C. albicans. We are targeting the various amino acids based on extension of previous group methods as well as literature precedent.

     

 

    

1) Qureshi, A.; Colin, P.L.; Faulkner, D.J. Tetrahedron 2000, 56, 3679-3685.