Paul Schuber
Department of Chemistry
Colorado State University
Fort Collins, CO 80521
Paul_Schuber@hotmail.com
In 2004, MCP1001 (1) was isolated from a fungal strain
Cladorrhinum sp. KY4922 in Indonesia and has subsequently shown
antiproliferative activity against a human prostate cancer cell line
(DU145).1 The structure was determined by numerous NMR experiments as
well as FAB-MS analysis.2 The characterization revealed a
fifteen-membered macrocycle containing a unique diketopiperazine with a
disulfide bridge fused to a seven-membered oxepin moiety. These unique
structural features belong to a class of compounds known as
epipolythiodioxopiperazines (ETP).
References
1.Ando, K.; Hasegawa, A.; Nakai, R.; Onodera, H.; Tsumagari, N.;
Yamashita, Y.; J. Antibiotics, (2004), 57, 532.
2. Hasegawa, A.; Kanda, Y.; Nakai, R.; Ogawa, T.; Onodera, H.;
Tsumagari, N.; J. Org. Chem. 2004, 22, 4101.
